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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737223
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL12
Name: C-X-C motif chemokine ligand 12
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL12decreases expressionISOCxcl12 (Mus musculus)6480464CTDStreptozocin results in decreased expression of CXCL12 mRNA; Streptozocin results in decreased expression of CXCL12 proteinPMID:18227068
CXCL12multiple interactionsISOCxcl12 (Mus musculus)6480464CTD[Streptozocin co-treated with Oxygen deficiency] results in decreased expression of CXCL12 mRNA; CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of KLF15 protein]; CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCN2 protein]; CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FN1 protein]; CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; KLF15 gene mutant form inhibits the reaction [CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCN2 protein]]; KLF15 gene mutant form inhibits the reaction [CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FN1 protein]]; KLF15 gene mutant form inhibits the reaction [CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[Streptozocin co-treated with Oxygen deficiency] results in decreased expression of CXCL12 mRNA]PMID:18227068 PMID:34310909
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