Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737058
Species: Mus musculus
RGD Object: Gene
Symbol: Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pik3cbmultiple interactionsEXP 6480464CTD[Streptozocin co-treated with Dietary Fats] results in decreased expression of PIK3CB protein; Dibutyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PIK3CB protein]; L 783281 inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PIK3CB protein]; L 783281 inhibits the reaction [Dibutyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of PIK3CB protein]]PMID:29526571
Pik3cbdecreases expressionISOPik3cb (Rattus norvegicus)6480464CTDStreptozocin results in decreased expression of PIK3CB mRNAPMID:26071184
Pik3cbmultiple interactionsISOPik3cb (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [Streptozocin results in decreased expression of PIK3CB mRNA]PMID:26071184
Go Back to source page   Continue to Ontology report