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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736023
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK9
Name: mitogen-activated protein kinase 9
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK9multiple interactionsEXP 6480464CTDStreptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK9 protein]PMID:25541468
MAPK9increases expressionISOMapk9 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of MAPK9 mRNAPMID:19190261
MAPK9multiple interactionsISOMapk9 (Rattus norvegicus)6480464CTDchromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]PMID:19190261
MAPK9multiple interactionsISOMapk9 (Mus musculus)6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAPK9 protein; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAPK9 protein]PMID:26522834
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