Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735849
Species: Homo sapiens
RGD Object: Gene
Symbol: EPO
Name: erythropoietin
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EPOdecreases expressionISOEpo (Rattus norvegicus)6480464CTDStreptozocin results in decreased expression of EPO proteinPMID:20821229
EPOincreases expressionISOEpo (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of EPO mRNAPMID:19958114 PMID:20821229
EPOmultiple interactionsISOEpo (Rattus norvegicus)6480464CTD[Dietary Fats co-treated with Streptozocin] results in decreased expression of EPO protein; dapagliflozin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of EPO protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]; Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPO protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]PMID:19958114 PMID:20821229 PMID:34391751
Go Back to source page   Continue to Ontology report