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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732642
Species: Mus musculus
RGD Object: Gene
Symbol: Oga
Name: O-GlcNAcase
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ogamultiple interactionsISOOga (Rattus norvegicus)6480464CTD[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein; dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein]PMID:30551545
Ogamultiple interactionsISOOGA (Homo sapiens)6480464CTDStreptozocin binds to and results in decreased activity of OGA proteinPMID:18721751
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