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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731305
Species: Homo sapiens
RGD Object: Gene
Symbol: NTRK2
Name: neurotrophic receptor tyrosine kinase 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NTRK2decreases expressionISONtrk2 (Rattus norvegicus)6480464CTDStreptozocin results in decreased expression of NTRK2 mRNAPMID:35414346
NTRK2decreases phosphorylationISONtrk2 (Mus musculus)6480464CTDStreptozocin results in decreased phosphorylation of NTRK2 proteinPMID:28499986
NTRK2multiple interactionsISONtrk2 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein]; Physostigmine inhibits the reaction [Streptozocin results in decreased phosphorylation of NTRK2 protein]PMID:28499986
NTRK2multiple interactionsISONtrk2 (Rattus norvegicus)6480464CTDMetformin inhibits the reaction [Streptozocin results in increased expression of NTRK2 mRNA]; morin inhibits the reaction [Streptozocin results in increased expression of NTRK2 mRNA]PMID:35414346
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