GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | VEGFA | decreases expression | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | Streptozocin results in decreased expression of VEGFA mRNA | PMID:11596663 | VEGFA | decreases secretion | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Streptozocin results in decreased secretion of VEGFA protein | PMID:35051763 | VEGFA | increases expression | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | Streptozocin results in increased expression of VEGFA mRNA; Streptozocin results in increased expression of VEGFA protein | PMID:14718351 PMID:15643138 PMID:17662242 PMID:18569938 PMID:19279317 PMID:20821229 PMID:20844835 PMID:22191573 PMID:25199697 PMID:32554039 | VEGFA | increases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Streptozocin results in increased expression of VEGFA mRNA; Streptozocin results in increased expression of VEGFA protein | PMID:17724226 PMID:22058332 PMID:26073000 | VEGFA | multiple interactions | ISO | Vegfa (Rattus norvegicus) | 6480464 | CTD | [Streptozocin co-treated with Cadmium] results in increased expression of VEGFA protein; ACE2 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; benazepril inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; cloricromen inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; manumycin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; Melatonin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of VEGFA protein]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; Taurine inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased expression of VEGFA mRNA]; turmeric extract inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; turmeric extract inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] | PMID:11596663 PMID:14718351 PMID:17662242 PMID:18569938 PMID:19279317 PMID:20821229 PMID:20844835 PMID:22191573 PMID:25199697 PMID:25240712 PMID:32554039 | VEGFA | multiple interactions | ISO | Vegfa (Mus musculus) | 6480464 | CTD | bisphenol A inhibits the reaction [Streptozocin results in decreased secretion of VEGFA protein]; dehydroxymethylepoxyquinomicin inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; dehydroxymethylepoxyquinomicin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]; Telmisartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA] | PMID:17724226 PMID:22058332 PMID:35051763 | | ||||||||||||||||||||||
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