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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731054
Species: Homo sapiens
RGD Object: Gene
Symbol: EPHX2
Name: epoxide hydrolase 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EPHX2decreases response to substanceISOEphx2 (Mus musculus)6480464CTDEPHX2 gene mutant form results in decreased susceptibility to StreptozocinPMID:21832210
EPHX2increases expressionISOEphx2 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of EPHX2 proteinPMID:23611540
EPHX2multiple interactionsISOEphx2 (Mus musculus)6480464CTDEPHX2 gene mutant form inhibits the reaction [Streptozocin results in increased activity of RELA protein]; EPHX2 gene mutant form inhibits the reaction [Streptozocin results in increased secretion of CCL2 protein]PMID:21832210
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