Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70918
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf15
Name: KLF transcription factor 15
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf15multiple interactionsISOKlf15 (Mus musculus)6480464CTD[Dietary Fats co-treated with Streptozocin] promotes the reaction [KLF15 gene mutant form results in increased expression of CCN2 protein]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of KLF15 protein; CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of KLF15 protein]; KLF15 gene mutant form inhibits the reaction [CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCN2 protein]]; KLF15 gene mutant form inhibits the reaction [CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FN1 protein]]; KLF15 gene mutant form inhibits the reaction [CXCL12 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]]; KLF15 gene mutant form promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCN2 protein]; KLF15 gene mutant form promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FN1 protein]; KLF15 gene mutant form promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; KLF15 gene mutant form results in increased susceptibility to [Dietary Fats co-treated with Streptozocin]PMID:34310909
Go Back to source page   Continue to Ontology report