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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69219
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aldh2decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of ALDH2 mRNA; Streptozocin results in decreased expression of ALDH2 proteinPMID:23500772
Aldh2increases expressionEXP 6480464CTDStreptozocin results in increased expression of ALDH2 proteinPMID:21136691
Aldh2multiple interactionsEXP 6480464CTDEthanol inhibits the reaction [Streptozocin results in decreased expression of ALDH2]PMID:23500772
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