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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases cleavageEXP 6480464CTDStreptozocin results in increased cleavage of CASP12 protein

PMID:25541178
multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]

PMID:25541178
increases cleavageISORGD:7314426480464CTDStreptozocin results in increased cleavage of CASP12 protein

PMID:24967692
increases expressionISORGD:7314426480464CTDStreptozocin results in increased expression of CASP12 protein modified form

PMID:23499715
multiple interactionsISORGD:7314426480464CTDFGF21 protein affects the reaction [Streptozocin results in increased expression of CASP12 protein modified form], sulforafan inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]

PMID:23499715, PMID:24967692
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.