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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDStreptozocin results in increased expression of CCN2 mRNA, Streptozocin results in increased expression of CCN2 protein

PMID:10026205, PMID:14586741, PMID:17270171, PMID:19369054, PMID:19895808, PMID:21416479, PMID:25057273, PMID:28648635
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Streptozocin results in increased expression of CCN2 protein], Aspirin inhibits the reaction [Streptozocin results in increased expression of CCN2 mRNA], Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein], fenugreek seed meal inhibits the reaction [Streptozocin results in increased expression of CCN2 mRNA], fenugreek seed meal inhibits the reaction [Streptozocin results in increased expression of CCN2 protein], idebenone inhibits the reaction [Streptozocin results in increased expression of CCN2 protein], XLF-III-43 inhibits the reaction [Streptozocin results in increased expression of CCN2 protein], Zinc inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]

PMID:14586741, PMID:17270171, PMID:19369054, PMID:19895808, PMID:21416479, PMID:25057273, PMID:28648635
increases expressionISORGD:7310146480464CTDStreptozocin results in increased expression of CCN2, Streptozocin results in increased expression of CCN2 protein

PMID:19657322, PMID:24967692
multiple interactionsISORGD:7310146480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of CCN2 protein, sulforafan inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CCN2 protein], sulforafan inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]

PMID:24707343, PMID:24967692
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.