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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620687
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pygl
Name: glycogen phosphorylase L
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pygldecreases expressionEXP 6480464CTDStreptozocin results in decreased expression of PYGL mRNAPMID:25905778
Pyglmultiple interactionsEXP 6480464CTD[Streptozocin co-treated with Niacinamide] affects the activity of PYGL protein; resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] affects the activity of PYGL protein]PMID:19059388
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