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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620265
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S100a8
Name: S100 calcium binding protein A8
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S100a8increases expressionISOS100a8 (Mus musculus)6480464CTDStreptozocin results in increased expression of S100A8 mRNAPMID:19833897
S100a8multiple interactionsISOS100a8 (Mus musculus)6480464CTD[Streptozocin co-treated with Dietary Fats] results in increased expression of S100A8 mRNA; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of S100A8 mRNA]PMID:19833897 PMID:29127188
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