GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sod2 | decreases activity | EXP | | 6480464 | CTD | Streptozocin results in decreased activity of SOD2 protein | PMID:19951573 PMID:20053369 PMID:22940631 | Sod2 | decreases expression | EXP | | 6480464 | CTD | Streptozocin results in decreased expression of SOD2 mRNA; Streptozocin results in decreased expression of SOD2 protein | PMID:18779489 PMID:19634143 PMID:20654064 PMID:25905778 PMID:34175429 PMID:35442559 | Sod2 | multiple interactions | EXP | | 6480464 | CTD | [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 mRNA]; [Ascorbic Acid co-treated with Vitamin E co-treated with beta Carotene co-treated with Copper] inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of SOD2 mRNA; [Streptozocin co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 protein; arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in decreased expression of SOD2 protein]; idebenone inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; INS protein promotes the reaction [Streptozocin results in decreased activity of SOD2 protein]; Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of and results in decreased activity of SOD2 protein]; Streptozocin results in decreased expression of and results in decreased activity of SOD2 protein; STUB1 inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; Thioctic Acid inhibits the reaction [Streptozocin results in decreased activity of SOD2 protein]; Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein] | PMID:14871415 PMID:18779489 PMID:19634143 PMID:19951573 PMID:20053369 PMID:21799698 PMID:22940631 PMID:34175429 PMID:35442559 PMID:35786680 | Sod2 | affects expression | ISO | Sod2 (Mus musculus) | 6480464 | CTD | Streptozocin affects the expression of SOD2 mRNA | PMID:22775417 | Sod2 | decreases expression | ISO | Sod2 (Mus musculus) | 6480464 | CTD | Streptozocin results in decreased expression of SOD2; Streptozocin results in decreased expression of SOD2 protein | PMID:21778425 PMID:22744176 PMID:26887929 PMID:28499986 | Sod2 | decreases response to substance | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | SOD2 protein results in decreased susceptibility to Streptozocin | PMID:15855331 | Sod2 | increases expression | ISO | Sod2 (Mus musculus) | 6480464 | CTD | Streptozocin results in increased expression of SOD2 mRNA | PMID:15298345 | Sod2 | multiple interactions | ISO | Sod2 (Mus musculus) | 6480464 | CTD | [Dietary Fats co-treated with Streptozocin] results in decreased expression of SOD2 mRNA; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of SOD2 mRNA; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]; ginsenoside Rh4 inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SOD2 mRNA]; Physostigmine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; Quercetin inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; SIRT1 protein inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]; SIRT1 protein inhibits the reaction [Streptozocin results in decreased expression of SOD2]; SOD2 protein inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein] | PMID:20976160 PMID:21778425 PMID:22744176 PMID:22775417 PMID:25362599 PMID:26887929 PMID:28499986 PMID:33359794 | Sod2 | multiple interactions | ISO | SOD2 (Homo sapiens) | 6480464 | CTD | CAT protein promotes the reaction [SOD2 protein results in decreased susceptibility to Streptozocin]; SOD2 protein promotes the reaction [CAT protein results in decreased susceptibility to Streptozocin] | PMID:15855331 | | ||||||||||||||||||||||
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