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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3031
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smad2
Name: SMAD family member 2
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smad2increases phosphorylationEXP 6480464CTDStreptozocin results in increased phosphorylation of SMAD2 proteinPMID:21300041
Smad2multiple interactionsEXP 6480464CTD[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased phosphorylation of SMAD2 protein; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of SMAD2 protein]PMID:21300041 PMID:31062909
Smad2multiple interactionsISOSmad2 (Mus musculus)6480464CTD[Huang Qi co-treated with Coptidis rhizoma extract co-treated with Aconitic Acid co-treated with Centella asiatica extract] inhibits the reaction [[Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD2 protein]; [Streptozocin co-treated with NG-Nitroarginine Methyl Ester] results in increased phosphorylation of SMAD2 proteinPMID:38282657
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