GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2492
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dcc
Name: DCC netrin 1 receptor
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:104656480464CTDStreptozocin results in increased expression of DCC mRNA

Streptozocin results in increased expression of DCC protein

PMID:29059224
multiple interactionsISORGD:104656480464CTDNTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC mRNA]

NTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC protein]

PMID:29059224
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.