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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDStreptozocin results in increased expression of CYP7A1 mRNA

PMID:10393316
multiple interactionsEXP 6480464CTD[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA, [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein, Fungal Polysaccharides inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA], Fungal Polysaccharides inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein], Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA], Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein]

PMID:31100278
multiple interactionsISORGD:104586480464CTD[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA, [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein

PMID:29382564
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.