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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3000
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lep
Name: leptin
Acc ID: CHEBI:9271
Term: stevioside
Definition: A diterpene glycoside that is rubusoside in which the hydroxy group at position 2 of the allylic beta-D-glucoside has been converted to the corresponding beta-D-glucoside. It is a natural herbal sweetener that is 250-300 times sweeter than sucrose (though with a bitter aftertaste), extracted from the Stevia rebaudiana plant native to South America.
Chemical ID: MESH:C012043
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepmultiple interactionsISORGD:691246480464CTDstevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CAT mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of CPT1A mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of DGAT2 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of FOXO1 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of G6PC mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of INSR mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS1 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of IRS2 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of LIPC mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of MTOR mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKB1 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of NFKBIA mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PCK1 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PLIN2 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARA mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARD mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARG mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of PPARGC1A mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SCD1 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SIRT1 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC27A1 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SLC2A2 mRNA] stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of SOD2 mRNA]

PMID:25554529
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