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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2599
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fcer1g
Name: Fc epsilon receptor Ig
Acc ID: CHEBI:92511
Term: ketotifen
Definition: An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Chemical ID: MESH:D007665
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fcer1gdecreases expressionEXP 6480464CTDKetotifen results in decreased expression of FCER1G proteinPMID:1834581
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