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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:92511
Term: ketotifen
Definition: An organic heterotricyclic compound that is 4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one which is substituted at position 4 by a 1-methylpiperidin-4-ylidene group. A blocker of histamine H1 receptors with a stabilising action on mast cells, it is used (usually as its hydrogen fumarate salt) for the treatment of asthma, where it may take several weeks to exert its full effect.
Chemical ID: MESH:D007665
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionISOIl1b (Rattus norvegicus)6480464CTDKetotifen results in increased expression of IL1B proteinPMID:15265675
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD[Ketotifen co-treated with nimesulide] results in decreased expression of IL1B proteinPMID:12121561
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