Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2325598
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Mir21
Name:	microRNA 21

Acc ID:	CHEBI:9243
Term:	sporidesmin A
Definition:	An organic heteropentacyclic compound that has formula C18H20ClN3O6S2, produced by the saprophyte fungus Pithomyces chartarum. It is a mycotoxin responsible for the hepatogenous photosensitisation disease facial eczema in ruminants.
Chemical ID:	MESH:C001873

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Mir21	increases expression	ISO	RGD:1349265	6480464	CTD	sporidesmin results in increased expression of MIR21 mRNA	PMID:28193462
Mir21	multiple interactions	ISO	RGD:1349265	6480464	CTD	MIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]; MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]	PMID:28193462

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