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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2325598
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mir21
Name: microRNA 21
Acc ID: CHEBI:9243
Term: sporidesmin A
Definition: An organic heteropentacyclic compound that has formula C18H20ClN3O6S2, produced by the saprophyte fungus Pithomyces chartarum. It is a mycotoxin responsible for the hepatogenous photosensitisation disease facial eczema in ruminants.
Chemical ID: MESH:C001873
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir21increases expressionISORGD:13492656480464CTDsporidesmin results in increased expression of MIR21 mRNAPMID:28193462
Mir21multiple interactionsISORGD:13492656480464CTDMIR21 mRNA affects the reaction [sporidesmin affects the expression of CYP2C8 mRNA]; MIR21 mRNA affects the reaction [sporidesmin results in increased expression of CYP2C18 mRNA]PMID:28193462
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