GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ACE | affects expression | ISO | Ace (Rattus norvegicus) | 6480464 | CTD | Spironolactone affects the expression of ACE protein | PMID:30734886 | ACE | decreases expression | ISO | Ace (Rattus norvegicus) | 6480464 | CTD | Spironolactone results in decreased expression of ACE protein | PMID:18586661 | ACE | multiple interactions | ISO | Ace (Rattus norvegicus) | 6480464 | CTD | Spironolactone inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Spironolactone inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] | PMID:15932931 | |
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