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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:9241
Term: spironolactone
Definition: A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.
Chemical ID: MESH:D013148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDSpironolactone results in increased expression of UGT1A1 mRNA

PMID:19144771
increases activityISORGD:39356480464CTDSpironolactone results in increased activity of UGT1A1 protein

PMID:12818378
increases expressionISORGD:39356480464CTDSpironolactone results in increased expression of UGT1A1 mRNA

PMID:12818378
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