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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71034
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr7
Name: 5-hydroxytryptamine receptor 7
Acc ID: CHEBI:9233
Term: spiperone
Definition: An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Chemical ID: MESH:D013134
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr7multiple interactionsISOHTR7 (Homo sapiens)6480464CTD[Spiperone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP]PMID:14578406
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