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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:9233
Term: spiperone
Definition: An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.
Chemical ID: MESH:D013134
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects bindingEXP 6480464CTDSpiperone binds to DRD2 proteinPMID:11927170 PMID:14559291 PMID:16137708 PMID:16889759 PMID:18457824 PMID:1975278 PMID:2018630 PMID:25522657 PMID:6149133 PMID:8804920 PMID:8829135
Drd2multiple interactionsEXP 6480464CTD8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Spiperone binds to DRD2 protein]; Amphetamine inhibits the reaction [Spiperone binds to DRD2 protein]; Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]; Cocaine affects the reaction [Spiperone binds to DRD2 protein]; Haloperidol inhibits the reaction [Spiperone binds to DRD2 protein]; manganese chloride inhibits the reaction [DRD2 protein binds to Spiperone]; N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]; perospirone inhibits the reaction [Spiperone binds to DRD2 protein]; Pilocarpine inhibits the reaction [Spiperone binds to DRD2 protein]; Pilocarpine promotes the reaction [Spiperone binds to DRD2 protein]; Remoxipride inhibits the reaction [Spiperone binds to DRD2 protein]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]]PMID:11927170 PMID:14559291 PMID:16137708 PMID:16889759 PMID:17161392 PMID:1975278 PMID:2018630 PMID:20729865 PMID:21484877 PMID:6149133
Drd2affects bindingISODrd2 (Mus musculus)6480464CTDSpiperone binds to DRD2 proteinPMID:11226678 PMID:2833825
Drd2affects bindingISODRD2 (Homo sapiens)6480464CTDSpiperone binds to DRD2 proteinPMID:20969853 PMID:21999579 PMID:8804920
Drd2multiple interactionsISODrd2 (Mus musculus)6480464CTDamitraz inhibits the reaction [Spiperone binds to DRD2 protein]; demethylchlordimeform inhibits the reaction [Spiperone binds to DRD2 protein]; NR3C1 protein promotes the reaction [Spiperone binds to DRD2 protein]PMID:11226678 PMID:2833825
Drd2multiple interactionsISODRD2 (Homo sapiens)6480464CTDMelitten inhibits the reaction [Spiperone binds to DRD2 protein]PMID:20969853
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