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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gria1
Name: glutamate ionotropic receptor AMPA type subunit 1
Acc ID: CHEBI:92211
Term: SL-327
Definition: A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4-aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.
Chemical ID: MESH:C424127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gria1multiple interactionsISOGria1 (Mus musculus)6480464CTDSL 327 inhibits the reaction [Cocaine results in increased phosphorylation of GRIA1 protein]PMID:16473939
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