GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Drd2 | affects binding | EXP | | 6480464 | CTD | Raclopride binds to DRD2 protein | PMID:7901417 PMID:8804920 | Drd2 | multiple interactions | EXP | | 6480464 | CTD | [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate; [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine; [Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamine; DRD2 protein affects the reaction [Raclopride results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Raclopride results in increased expression of GSK3A protein]; Raclopride binds to and results in decreased activity of DRD2 protein; Saponins inhibits the reaction [Raclopride binds to DRD2 protein] | PMID:11454915 PMID:15341276 PMID:15542624 PMID:16144542 PMID:16251992 PMID:1833784 PMID:19289156 | Drd2 | affects binding | ISO | Drd2 (Mus musculus) | 6480464 | CTD | Raclopride binds to DRD2 protein; Raclopride binds to DRD2 protein alternative form | PMID:12476322 PMID:12673668 PMID:14756803 PMID:17948891 PMID:20169576 PMID:9533112 | Drd2 | affects binding | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | Raclopride binds to DRD2; Raclopride binds to DRD2 protein | PMID:15010698 PMID:18058087 PMID:19439595 PMID:8804920 | Drd2 | increases response to substance | ISO | Drd2 (Mus musculus) | 6480464 | CTD | DRD2 protein alternative form results in increased susceptibility to Raclopride | PMID:12476322 | Drd2 | multiple interactions | ISO | Drd2 (Mus musculus) | 6480464 | CTD | Amlodipine inhibits the reaction [Raclopride binds to DRD2 protein]; bisphenol A promotes the reaction [Raclopride binds to DRD2 protein]; Diltiazem inhibits the reaction [Raclopride binds to DRD2 protein]; Flunarizine inhibits the reaction [Raclopride binds to DRD2 protein]; manidipine inhibits the reaction [Raclopride binds to DRD2 protein]; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; Verapamil inhibits the reaction [Raclopride binds to DRD2 protein] | PMID:20169576 PMID:8103921 PMID:9533112 | Drd2 | multiple interactions | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | [Dopamine co-treated with Raclopride] promotes the reaction [Dopamine binds to DRD2 protein]; Cocaine affects the reaction [Raclopride binds to DRD2] | PMID:15010698 PMID:19439595 | |
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