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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737309
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:920
Term: 2,4-dinitrotoluene
Definition: A dinitrotoluene in which the methyl group is ortho to one of the nitro groups and para to the other. It is the most common isomer of dinitrotoluene.
Chemical ID: MESH:C016403
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARAaffects response to substanceISOPpara (Mus musculus)6480464CTDPPARA gene mutant form affects the susceptibility to 2,4-dinitrotoluenePMID:24893713
PPARAdecreases activityISOPpara (Mus musculus)6480464CTD2,4-dinitrotoluene results in decreased activity of PPARA proteinPMID:24893713
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