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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737424
Species: Homo sapiens
RGD Object: Gene
Symbol: MYH11
Name: myosin heavy chain 11
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MYH11increases expressionEXP 6480464CTDSirolimus results in increased expression of MYH11 proteinPMID:17908691
MYH11multiple interactionsEXP 6480464CTD[Sirolimus co-treated with IGF1 protein] results in increased expression of MYH11 protein; [Sirolimus results in increased activity of AKT2 protein] which results in increased expression of MYH11 proteinPMID:17908691
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