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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621634
Species: Mus musculus
RGD Object: Gene
Symbol: Bglap
Name: bone gamma carboxyglutamate protein
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bglapmultiple interactionsEXP 6480464CTDSirolimus inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA]]PMID:33450223
Bglapmultiple interactionsISOBGLAP (Homo sapiens)6480464CTDSirolimus inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]PMID:23111315
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