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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347014
Species: Homo sapiens
RGD Object: Gene
Symbol: RPL32
Name: ribosomal protein L32
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RPL32decreases expressionEXP 6480464CTDSirolimus results in decreased expression of RPL32 proteinPMID:25940091
RPL32multiple interactionsEXP 6480464CTDLARP1 protein promotes the reaction [Sirolimus results in decreased expression of RPL32 protein]; Sirolimus inhibits the reaction [EIF4G1 protein binds to RPL32 mRNA]; Sirolimus promotes the reaction [LARP1 protein binds to RPL32 mRNA]PMID:25940091
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