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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343198
Species: Homo sapiens
RGD Object: Gene
Symbol: KLK3
Name: kallikrein related peptidase 3
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KLK3increases expressionEXP 6480464CTDSirolimus results in increased expression of KLK3 proteinPMID:18776922
KLK3multiple interactionsEXP 6480464CTDbicalutamide inhibits the reaction [Sirolimus results in increased expression of KLK3 protein]PMID:18776922
KLK3decreases expressionISOKlk1c10 (Rattus norvegicus)6480464CTDSirolimus results in decreased expression of KLK1C10 mRNAPMID:21865292
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