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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313299
Species: Homo sapiens
RGD Object: Gene
Symbol: MDM2
Name: MDM2 proto-oncogene
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MDM2decreases expressionEXP 6480464CTDSirolimus results in decreased expression of MDM2 proteinPMID:19560264
MDM2multiple interactionsEXP 6480464CTDEIF4E protein inhibits the reaction [Sirolimus results in decreased expression of MDM2 protein]; Sirolimus inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]; Sirolimus promotes the reaction [TP73 protein binds to MDM2 promoter]PMID:15625077 PMID:19560264 PMID:21245298
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