GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Apoe | affects response to substance | EXP | | 6480464 | CTD | APOE affects the susceptibility to Simvastatin | PMID:11947894 | Apoe | affects response to substance | ISO | APOE (Homo sapiens) | 6480464 | CTD | APOE polymorphism affects the susceptibility to Simvastatin | PMID:11849659 PMID:12901521 | Apoe | decreases expression | ISO | Apoe (Rattus norvegicus) | 6480464 | CTD | Simvastatin results in decreased expression of APOE mRNA; Simvastatin results in decreased expression of APOE protein | PMID:25055962 PMID:8289597 PMID:8461338 | Apoe | decreases expression | ISO | APOE (Homo sapiens) | 6480464 | CTD | Simvastatin results in decreased expression of APOE; Simvastatin results in decreased expression of APOE mRNA | PMID:18270459 PMID:19461118 | Apoe | multiple interactions | ISO | Apoe (Rattus norvegicus) | 6480464 | CTD | Polystyrenes analog inhibits the reaction [Simvastatin results in decreased expression of APOE protein] | PMID:8461338 | |
Go Back to source page | Continue to Ontology report |