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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730944
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCB11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCB11decreases activityEXP 6480464CTDSimvastatin results in decreased activity of ABCB11 proteinPMID:20829430 PMID:23956101 PMID:24014644
ABCB11multiple interactionsEXP 6480464CTDSimvastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]PMID:24014644
ABCB11decreases expressionISOAbcb11 (Rattus norvegicus)6480464CTDSimvastatin results in decreased expression of ABCB11 mRNAPMID:27765674
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