Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69005
Species: Mus musculus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3affects expressionEXP 6480464CTDSimvastatin affects the expression of STAT3 proteinPMID:17507688
Stat3decreases activityEXP 6480464CTDSimvastatin results in decreased activity of STAT3 proteinPMID:19886038
Stat3decreases activityISOSTAT3 (Homo sapiens)6480464CTDSimvastatin results in decreased activity of STAT3 proteinPMID:19886038
Stat3decreases phosphorylationISOStat3 (Rattus norvegicus)6480464CTDSimvastatin results in decreased phosphorylation of STAT3 proteinPMID:18400235
Stat3decreases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDSimvastatin results in decreased phosphorylation of STAT3 proteinPMID:18453621 PMID:21910007
Stat3multiple interactionsISOStat3 (Rattus norvegicus)6480464CTDMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein modified form]; Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT3 protein]; Simvastatin inhibits the reaction [CTF1 results in increased phosphorylation of STAT3 protein]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of STAT3 protein]PMID:16534557 PMID:18400235 PMID:19100119 PMID:20821229
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTDMevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT3 protein]PMID:18453621
Go Back to source page   Continue to Ontology report