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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68997
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF1R
Name: insulin like growth factor 1 receptor
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1Rdecreases expressionEXP 6480464CTDSimvastatin results in decreased expression of IGF1R; Simvastatin results in decreased expression of IGF1R mRNA; Simvastatin results in decreased expression of IGF1R proteinPMID:17158816 PMID:18489904
IGF1Rincreases expressionISOIgf1r (Mus musculus)6480464CTDSimvastatin results in increased expression of IGF1R protein alternative formPMID:17327694
IGF1Rmultiple interactionsISOIgf1r (Mus musculus)6480464CTD[Simvastatin co-treated with NVP-AEW541] inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]; Simvastatin inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]PMID:27734117
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