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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620763
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn1
Name: cellular communication network factor 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn1decreases expressionISOCCN1 (Homo sapiens)6480464CTDSimvastatin results in decreased expression of CCN1 mRNAPMID:17428261
Ccn1multiple interactionsISOCCN1 (Homo sapiens)6480464CTDSimvastatin inhibits the reaction [CCN1 results in increased expression of IL1B]; Simvastatin inhibits the reaction [CCN1 results in increased expression of OSM]; Simvastatin inhibits the reaction [CCN1 results in increased expression of TNF]; Simvastatin inhibits the reaction [OSM results in increased expression of CCN1 mRNA]PMID:20191585
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