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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620103
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bad
Name: BCL2-associated agonist of cell death
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baddecreases phosphorylationISOBad (Mus musculus)6480464CTDSimvastatin results in decreased phosphorylation of BAD proteinPMID:27734117
Baddecreases phosphorylationISOBAD (Homo sapiens)6480464CTDSimvastatin results in decreased phosphorylation of BAD proteinPMID:12438947
Badmultiple interactionsISOBad (Mus musculus)6480464CTDIGF1 protein inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]PMID:27734117
Badmultiple interactionsISOBAD (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]PMID:12438947
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