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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: F2
Name: coagulation factor II, thrombin
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2decreases activityISOF2 (Homo sapiens)6480464CTDSimvastatin results in decreased activity of F2 proteinPMID:14630613
F2multiple interactionsISOF2 (Homo sapiens)6480464CTDCycloheximide inhibits the reaction [Simvastatin results in decreased activity of F2 protein]; Simvastatin affects the reaction [F2 affects the localization of CTTN protein]; Simvastatin inhibits the reaction [F2 protein results in decreased expression of ENTPD1 protein]PMID:12067895 PMID:14630613
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