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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]], Simvastatin inhibits the reaction [CTF1 results in increased expression of STAT1 protein]

PMID:16534557
decreases activityISORGD:7321846480464CTDSimvastatin results in decreased activity of STAT1 protein

PMID:19886038
decreases activityISORGD:7321856480464CTDSimvastatin results in decreased activity of STAT1 protein

PMID:19886038
decreases expressionISORGD:7321846480464CTDSimvastatin results in decreased expression of STAT1 mRNA

PMID:21268089
decreases expressionISORGD:7321856480464CTDSimvastatin results in decreased expression of STAT1 mRNA, Simvastatin results in decreased expression of STAT1 protein

PMID:17507688
decreases phosphorylationISORGD:7321846480464CTDSimvastatin results in decreased phosphorylation of STAT1 protein

PMID:18453621
multiple interactionsISORGD:7321846480464CTDMevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT1 protein], Simvastatin inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]

PMID:18453621, PMID:21268089
multiple interactionsISORGD:7321856480464CTDgeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA], geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein], Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA], Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein], Simvastatin inhibits the reaction [IFNG promotes the reaction [STAT1 binds to CD40 promoter]], Simvastatin inhibits the reaction [IFNG results in increased phosphorylation of STAT1 protein]

PMID:17507688
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.