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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jundecreases expressionEXP 6480464CTDSimvastatin results in decreased expression of JUN mRNAPMID:12963647
Junincreases phosphorylationEXP 6480464CTDSimvastatin results in increased phosphorylation of JUN proteinPMID:15488325
Jundecreases localizationISOJUN (Homo sapiens)6480464CTDSimvastatin results in decreased localization of JUN proteinPMID:12753293
Junincreases phosphorylationISOJun (Mus musculus)6480464CTDSimvastatin results in increased phosphorylation of JUN proteinPMID:15187114
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDSimvastatin results in increased phosphorylation of JUN proteinPMID:17125918
Junmultiple interactionsISOJun (Mus musculus)6480464CTDJUN promotes the reaction [Simvastatin results in increased expression of IL12B mRNA]; Simvastatin affects the reaction [lipopolysaccharide, E coli O55-B5 promotes the reaction [JUN protein binds to JUNB protein binds to FOS protein binds to FOSB protein binds to FOSL2 protein]]; Simvastatin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of JUN protein]PMID:15187114
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [Simvastatin results in increased phosphorylation of JUN protein]PMID:17125918
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