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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il18
Name: interleukin 18
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il18multiple interactionsEXP 6480464CTDMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]]; Simvastatin inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA]PMID:18660453
Il18multiple interactionsISOIL18 (Homo sapiens)6480464CTDSimvastatin promotes the reaction [Lipopolysaccharides results in increased secretion of IL18 protein]PMID:27377765
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