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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2199
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2
Name: BCL2, apoptosis regulator
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of BCL2 proteinPMID:25300705
Bcl2decreases expressionISOBcl2 (Mus musculus)6480464CTDSimvastatin results in decreased expression of BCL2 mRNAPMID:25300705
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDSimvastatin results in decreased expression of BCL2 mRNA; Simvastatin results in decreased expression of BCL2 proteinPMID:17901590 PMID:18031796 PMID:18521906 PMID:21729534
Bcl2increases expressionISOBcl2 (Mus musculus)6480464CTDSimvastatin results in increased expression of BCL2 mRNA; Simvastatin results in increased expression of BCL2 proteinPMID:17241114
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDSimvastatin results in increased expression of BCL2 proteinPMID:17241114
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTDgeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of BCL2 mRNA]; Simvastatin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; Simvastatin promotes the reaction [NFATC3 protein binds to BCL2 promoter]PMID:17277159 PMID:18031796 PMID:20369390
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