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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345262
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP51A1
Name: cytochrome P450 family 51 subfamily A member 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP51A1increases expressionISOCyp51 (Rattus norvegicus)6480464CTDSimvastatin results in increased expression of CYP51 mRNAPMID:25055962
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