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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319403
Species: Homo sapiens
RGD Object: Gene
Symbol: FOXO3
Name: forkhead box O3
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FOXO3affects localizationISOFoxo3 (Mus musculus)6480464CTDSimvastatin affects the localization of FOXO3 proteinPMID:27734117
FOXO3decreases expressionISOFoxo3 (Rattus norvegicus)6480464CTDSimvastatin results in decreased expression of FOXO3 proteinPMID:19001041
FOXO3decreases phosphorylationISOFoxo3 (Rattus norvegicus)6480464CTDSimvastatin results in decreased phosphorylation of FOXO3 proteinPMID:19001041
FOXO3increases phosphorylationISOFoxo3 (Mus musculus)6480464CTDSimvastatin results in increased phosphorylation of FOXO3 proteinPMID:20883752
FOXO3multiple interactionsISOFoxo3 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Simvastatin results in increased phosphorylation of FOXO3 protein]; IGF1 protein inhibits the reaction [Simvastatin affects the localization of FOXO3 protein]PMID:20883752 PMID:27734117
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