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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735622
Species: Mus musculus
RGD Object: Gene
Symbol: Gdf15
Name: growth differentiation factor 15
Acc ID: CHEBI:9144
Term: silibinin
Definition: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
Chemical ID: MESH:C440975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdf15increases expressionISOGDF15 (Homo sapiens)6480464CTDSilybin results in increased expression of GDF15 mRNA; Silybin results in increased expression of GDF15 proteinPMID:24440808
Gdf15multiple interactionsISOGDF15 (Homo sapiens)6480464CTDEGR1 mutant form inhibits the reaction [Silybin results in increased expression of GDF15 protein]; GDF15 mutant form inhibits the reaction [Silybin results in increased cleavage of PARP1 protein]; pyrazolanthrone promotes the reaction [Silybin results in increased expression of GDF15 protein]; SB 203580 inhibits the reaction [Silybin results in increased expression of GDF15 protein]PMID:24440808
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