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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730886
Species: Homo sapiens
RGD Object: Gene
Symbol: CREB1
Name: cAMP responsive element binding protein 1
Acc ID: CHEBI:9130
Term: sevoflurane
Definition: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Chemical ID: MESH:C009250
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CREB1decreases expressionISOCreb1 (Rattus norvegicus)6480464CTDSevoflurane results in decreased expression of CREB1 mRNAPMID:30842370
CREB1decreases expressionISOCreb1 (Mus musculus)6480464CTDSevoflurane results in decreased expression of CREB1 proteinPMID:35350913
CREB1decreases phosphorylationISOCreb1 (Rattus norvegicus)6480464CTDSevoflurane results in decreased phosphorylation of CREB1 proteinPMID:30842370
CREB1multiple interactionsISOCreb1 (Rattus norvegicus)6480464CTDVorinostat inhibits the reaction [Sevoflurane results in decreased expression of CREB1 mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in decreased phosphorylation of CREB1 protein]PMID:30842370
CREB1multiple interactionsISOCreb1 (Mus musculus)6480464CTDalpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of CREB1 protein]PMID:35350913
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