Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:9130
Term: sevoflurane
Definition: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Chemical ID: MESH:C009250
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1decreases expressionEXP 6480464CTDSevoflurane results in decreased expression of HMOX1 mRNA; Sevoflurane results in decreased expression of HMOX1 proteinPMID:37494465
Hmox1multiple interactionsEXP 6480464CTD6,7-dihydroxyflavone inhibits the reaction [TBX2 protein inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 mRNA]]; 6,7-dihydroxyflavone inhibits the reaction [TBX2 protein inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 protein]]; TBX2 protein inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 mRNA]; TBX2 protein inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 protein]; TBX2 protein promotes the reaction [Sevoflurane results in decreased expression of HMOX1 protein]PMID:37494465
Hmox1decreases expressionISOHmox1 (Mus musculus)6480464CTDSevoflurane results in decreased expression of HMOX1 mRNA; Sevoflurane results in decreased expression of HMOX1 proteinPMID:35350913
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTDalpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 mRNA]; alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of HMOX1 protein]PMID:35350913
Go Back to source page   Continue to Ontology report